Achaete-Scute Genes and Neural Differentiation in the Hindbrain

93-09803温伯格 神经系统发育出无数种细胞类型， $ !. !. ! F 一群看似同质的细胞 负责开发这些不同细胞类型的机制仍然知之甚少。 一个家族的基因，无毛鳞片同源物，已被确定的蛋白质产物似乎参与这一过程。 该家族的两个新成员最近被发现，并将在本项目中进一步分析。 这些基因表达在发育中的后肢非常特定的区域。 这些区域包含在这些基因首次表达后不久将发育神经元的细胞。 该项目将寻求识别表达这些基因的特定细胞，并确定这些基因的表达是否是这些细胞特定命运发展的先决条件。 这个项目将对理解后脑发育有重大的进展，并将为神经系统中不同细胞类型如何产生的更普遍的问题提供新的见解。 $ $ " $ !. !. !. !. !. !. !. !. !. ( Times New Roman 符号Arial O O O D J d N O @ " $ $ " H jet eq e C 温伯格 William普罗克特，IBN William普罗克特，IBN

93-09803 Weinberg The nervous systems develops a myriad of cell types from $ !. !. ! F a seemingly homogeneous population of cells. The mechanisms responsible for developing these different cell types are still poorly understood. A family of genes, achaete-scute homologues, have been identified whose protein products appear to be involved in this process. Two new members of this family have recently been identified and will be further analyzed in this project. These genes are expressed in very specific regions of the developing hindbra in. These regions contain cell that will develop neurons shortly after these genes are first expressed. This project will seek to identify the specific cells that express these genes and to determine whether expression of these genes is a prerequisite for development of the specific fates of these cells. This project should make significant inroads into understanding hindbrain development and will offer new insights into the more general question of how different cell types arise in the nervous system $ $ " $ !. !. !. !. !. !. !. !. !. ( Times New Roman Symbol & Arial o o o D J d N O @ " $ $ " h j et eq e C weinberg William Proctor, IBN William Proctor, IBN