Interferon-g Regulation of Developing Central Cholinergic Neurons

小行星9311024 在过去的几年里，人们越来越清楚地认识到，最初被鉴定为对免疫系统中细胞的生长和发育有影响的分子在神经系统中起着类似的作用。 例如，干扰素-g（IFN-g），最初描述其在免疫系统中的抗病毒活性，现在已经显示影响脑中含乙酰胆碱的神经细胞群体的发育。这些神经细胞特别令人感兴趣，因为它们有助于学习和记忆的功能。 在初步研究中，IFN已被证明可以促进这些神经细胞培养物中乙酰胆碱的产生。该项目将确定IFN-g是否对这些细胞的生存或发育产生影响，IFN-g是否直接作用于神经细胞或通过另一种细胞类型，IFN-g是否通常存在于发育中的大脑中，以及它是否通常需要乙酰胆碱神经细胞发育或存活。 这些实验将增加我们对控制神经系统正常生长和发育的因素的理解。 *** 有效果 ! ! F u u ( Times New Roman 符号Arial S S S " H E E J O C 若纳凯特 William普罗克特，IBN William普罗克特，IBN

9311024 Jonakait It has become increasingly clear over the past few years that molecules originally identified as having effects on the growth and development of cells in the immune system play similar roles in the nervous system. For example, interferon-g (IFN-g), first described for its anti-viral activity in the immune system, has now been shown to affect the development of a population of acetylcholine-containing nerve cells in the brain. These nerve cells are of particular interest since they subserve functions of learning and memory. In preliminary studies, IFN has been shown to promote the production of acetylcholine in cultures of these nerve cells. This project will determine whether IFN-g exerts its effect on the survival or the development of these cells, whether IFN-g acts directly on the nerve cells or through another cell type, whether IFN-g is normally present in developing brain, and whether it is normally required for acetylcholine-nerve cell development or survival. These experiments will increase our understanding of factors that control normal growth and development of the nervous system. *** having eff ! ! F u u ( Times New Roman Symbol & Arial s s s " h E E J o C jonakait William Proctor, IBN William Proctor, IBN