NSF Young Investigator

这是国家科学基金会青年研究者奖。 获奖者正在使用遗传、生化和细胞相结合的方法 生物学方法来了解中心体（纺锤极） 体）在细胞中复制，使用酵母作为模型细胞 酿酒酵母 %%% 中心体是一种亚细胞器，由一种高度 一组有组织的微管。 它就像一个微管 细胞的组织中心，对细胞的生长过程至关重要。 分裂。 在细胞分裂过程中， 细胞，包含在染色体中，平均分配在 两个子细胞通过微管排列成一个 有丝分裂纺锤体 在有丝分裂过程中， 染色体从纺锤体的中心被拖到 在主轴的相对端的两个极，使得通过端部， 在这个过程中，每个极点都包含适当的染色体， 每个子细胞分离完成 这个过程是 由中心体控制，其中一个位于每一个极点， 主轴。 在细胞分裂结束时，每个子细胞 从其中一个纺锤体接收染色体和中心体 波兰人 因此，中心体必须在另一轮的细胞分裂之前复制。 细胞分裂可以完成。 该项目将使用现代 分子和细胞生物学方法，包括使用 中心体复制缺陷的酵母突变体， 中心体是如何复制和发挥作用的。

This is a National Science Foundation Young Investigator Award. The awardee is using a combined genetic, biochemical, and cell biological approach to understand how centrosomes (spindle pole bodies) replicate in cells, using as a model cell the yeast Saccharomyces cerevisiae. %%% The centrosome is a subcellular organelle made up of a highly organized set of microtubules. It serves as a microtubule organizing center for the cell, and is critical to the process of mitosis. During cell division, the genetic information of the cell, contained in the chromosomes, is apportioned equally between the two daughter cells by means of microtubules arrayed in a structure called the mitotic spindle. During the mitotic process, chromosomes are dragged from the center of the spindle to either of the two poles at opposite ends of the spindle, such that by the end of the process each pole contains the appropriate chromosomes for each daughter cell and the separation is complete. This process is controlled by the centrosomes, one of which sits at each pole of the spindle. At the end of cell division, each daughter cell receives the chromosomes and centrosome from one of the spindle poles. Thus, the centrosome must replicate before another round of cell division can be completed. This project will use modern molecular and cellular biology approaches, including the use of yeast mutants defective in centrosome replication, to understand how centrosomes replicate and function.