Solution Properties of Hydrogen-Bonding Polymers and Co-Polymers

9407741平卡斯这项理论研究将在圣巴巴拉的加州大学和洛杉矶的加州大学进行。将对由于溶剂分子与链上部分之间形成氢键而可溶于水溶剂的聚合物进行分析和模拟研究，例如，聚环氧乙烷主链上的氧。特别关注的是氢键的化学性质和与烃主链相关的疏水相互作用之间的相互作用。这些不带电荷的水溶性聚合物在与无机溶剂的使用相关的技术问题上具有重要的应用，并且还作为一类生物聚合物的活性和功能的模型。这项工作将扩展到共聚物，其中一部分具有氢键的字符和其他部分是一个更典型的烃。此类共聚物是药物递送系统中囊泡稳定剂的潜在候选者。%这项理论研究将在圣巴巴拉的加州大学和洛杉矶的加州大学进行。分析和模拟研究将在聚合物是可溶于水的。***

9407741 Pincus This theoretical research will be carried out at both the University of California at Santa Barbara and the University of California at Los Angeles. Analytical and simulational investigations will be done on polymers which are soluble in aqueous solvents because of hydrogen bond formation between the solvent molecules and the moities on the chain, e.g., oxygen on the backbone of polyethylene oxide. The particular focus will be on the interplay between the chemical nature of the hydrogen bond and the hydrophobic interaction associated with the hydrocarbon backbone. These uncharged hydrosoluble polymers have important applications to technological issues associated with the use of inorganic solvents and also as models for the activity and function of a class of biopolymers. The work will be extended to copolymers where one part has hydrogen bonding character and the other part is a more typical hydrocarbon. Such copolymers are potential candidates for vesicle stabilizers in drug delivery systems. %%% This theoretical research will be carried out at both the University of California at Santa Barbara and the University of California at Los Angeles. Analytical and simulational investigations will be done on polymers which are soluble in water. ***