Countdown to death: defining new signalling events preceding cell death

这项提议旨在了解程序性细胞死亡分子机制如何通过识别调控这些基本生物过程的新分子来促进先天免疫反应和增殖。这个项目希望通过创新的方法来加强我们对细胞死亡、细胞增殖和先天免疫的基本理解，并建立跨学科的合作。在这些关键过程中产生的新知识将成为开发生物医药行业创新应用的肥沃土壤。这将对澳大利亚社会的健康和经济产生积极影响。

This proposal aims to understand how programmed cell death molecular machineries promote innate immune responses and proliferation by identifying new molecules that regulate these fundamental biological processes. This project expects to enhance our basic understanding of cell death, cell proliferation and innate immunity using innovative approaches and to build interdisciplinary collaborations. The new generated knowledge in these critical processes will be fertile ground to develop innovative applications in biomedical industries. This this will have a positive impact on the health and economy of Australian society.