Anti-Idiotypic Antibodies as Probes of Plant Microtubule- Associated Proteins

9415479莫尔约翰这是探索性研究的一小笔助学金。该项目是对植物中微管相关蛋白(MAP)的一次捕鱼探险，使用一种基于生产抗独特型抗体作为试剂的高风险、创新的方法来识别假定的MAP。在动物系统中，微管相关蛋白(MAPs)在蛋白质结构和功能方面都有很大的了解。这些图谱在稳定微管和调节微管的组装和拆卸方面发挥了关键作用。在植物中，还没有实现对任何图谱的普遍接受的识别。由于微管在植物细胞的基本生命过程中起着关键作用，而且它们是一类重要除草剂的作用靶标，因此有必要增加我们对植物微管结构和功能的了解，包括图谱的鉴定。这个项目是识别植物地图的一种高风险但看似合理的方法。***

9415479 Morejohn This is a Small Grant for Exploratory Research. The project is a fishing expedition for microtubule-associated proteins (MAPs) in plants, using a high-risk, innovative approach based on the production of anti-idiotypic antibodies as reagents for identifying putative MAPs. %%% In animal systems, a lot is known about microtubule- associated proteins (MAPs), in terms of both protein structure and functions. These MAPs play critical roles in stabilizing microtubules and regulating the assembly and disassembly of microtubules. In plants, a generally accepted identification of any MAP has not yet been achieved. Since microtubules play critical roles in the fundamental life processes of plant cells, and since they are the targets of action of an important class of herbicides, there is compelling reason to increase our understanding of microtubule structure and function in plants, including the identification of MAPs. This project is a high-risk but plausible approach to the identification of plant MAPs. ***