Redefining how T cell recognition drives T cell activation

该建议旨在定义决定T细胞如何识别和应答外来抗原的关键机制；定义有效免疫的关键特征。为了实现这一目标，本提案将利用多学科合作和创新方法来了解T细胞受体识别的结构和生化特征如何影响T细胞介导的免疫和发育。反过来，该项目将促进T细胞生物学这一新兴领域的进一步研究和发展，并推动澳大利亚的生命科学研究。此外，由于T细胞生物学与所有脊椎动物都有关，因此这项研究将极大地有利于濒危动物物种的保护和农业。

This proposal aims to define the key mechanisms that determine how T cells recognise and respond to foreign antigens; a critical feature that defines effective immunity. To achieve this goal, this proposal will leverage multidisciplinary collaborations and innovative methods to understand how structural and biochemical features of T cell receptor recognition influences T cell mediated immunity and development. In turn, this project will facilitate further research and development in the burgeoning field of T cell biology and advance life science research in Australia. Furthermore, as T cell biology is relevant to all vertebrates, this research will greatly benefit the conservation of threatened animal species and agriculture.