Neural-Glial Interactions in the Developing Moth Wing

9421890纳尔迪在神经发育和再生过程中，神经元的过程往往必须经过很长的距离才能到达它们的目标。在这个生长阶段，神经元会遇到许多引导其导航的信号，包括细胞黏附分子、其他神经元和神经胶质细胞。这项研究试图确定神经胶质细胞在引导生长中的神经过程达到合适的目标方面所起的作用。要做到这一点，将使用一种新的模型系统。在昆虫的翅膀中，神经过程必须从翅膀的底部导航到顶端。在这一过程中，神经过程在精确定义的位置遇到神经胶质细胞，这些过程经常在这些位置转动。在这项研究中，神经胶质细胞将被移植到不同的位置，以直接确定神经细胞的存在与否是否影响神经过程做出适当指导选择的概率。如果事实证明是这样的话，进一步的实验将寻求确定神经胶质细胞提供的引导信号的分子基础。这将提供有关神经胶质细胞在神经系统发育和再生中所起作用的基本信息。

9421890 Nardi During neural development and regeneration, the processes of neurons often must navigate long distances to reach their targets. During this growth phase, the neuron encounters many cues that guide its navigation, including cell adhesion molecules, other neurons, and glial cells. This research seeks to define the role that glial cells play in guiding growing neural processes to their appropriate target. To do this, a novel model system will be used. In the insect wing, neural processes must navigate from the base of the wing to the tip. Along the way, the neural processes encounter glial cells at precisely defined positions, positions at which these processes often turn. In this research, glial cells will be transplanted to different positions to directly determine if the presence or absence of glial cells influences the probability that the neural processes will make the appropriate guidance choice. If this proves to be the case, further experiments will seek to define the molecular basis of the guidance cues provided by glial cells. This will provide fundamental information concerning the role that glia play in nervous system development and regeneration.