Antibody Catalysis

有了这一续期奖，合成有机计划将支持麻省理工学院化学系的Satoru Masamune博士的研究。Masamune教授将把工作重点放在开发生产催化抗体的策略上。我们的目标是找到活性与天然酶相当的催化剂。这项研究的重点是半抗原的设计和合成，以及使用同源和异种免疫来生产催化抗体。目标催化剂包括天冬氨酸蛋白酶样抗体、与外部亲核试剂酰胺键断裂的催化抗体和糖苷酶抗体。

With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Satoru Masamune of the Department of Chemistry at the Massachusetts Institute of Technology. Professor Masamune will focus his work on developing strategies for the production of catalytic antibodies. The goal is to find catalysts whose activities are comparable to those of their natural enzyme counterparts. The focus of this research is hapten design and synthesis and the use of both homologous and heterologous immunization for the production of catalytic antibodies. Target catalysts include aspartic protease-like antibodies, catalytic antibodies for amide bond cleavage with an external nucleophile and glycosidase antibodies.