NSF Young Investigator: Methodology and Strategy in the Synthesis of Marine Alkaloids and Related Compounds

9457359霍恩哥伦比亚大学新的合成方法和策略将在NSF青年研究员奖下开发，用于构建结构复杂的胍基海洋天然产物，具有重要的生物活性。研究将集中在2-氨基咪唑的化学性质上，其中主要目标是蛤蚌毒素和相关的性腺毒素生物碱。最近发现的2-氨基咪唑的2 + 4 -环加成反应将用于生成四氢嘌呤，这将使合成蛤蚌毒素和gonyautoxins的途径缩短。这项来自有机动力学计划的拨款支持哥伦比亚大学大卫·霍恩教授的研究。将合成含有碱性氮原子（生物碱）的海洋天然化合物。一些要合成的生物碱是在红潮中发现的神经毒素。在这项研究的过程中，预计将开发新的合成方法以及更短的途径来获得天然存在的生物碱。即将合成的相关化合物具有潜在的有趣的药用特性。

9457359 Horne Columbia University New synthetic methodologies and strategies will be developed uner this NSF Young Investigator Award for the construction of structurally complex guanidine-based marine natural products possessing important biological activities. The research will focus on the chemistry of 2-aminoimidazoles, where key targets are saxitoxin and related gonyautoxin alkaloids. A recently discovered 2 + 4 -cycloaddition reaction of 2-aminoimidazoles will be employed to generate tetrahydropurines, which will allow a short synthetic route to saxitoxin and gonyautoxins. This grant from the Organic Dynamics Program supports the research of Professor David A. Horne at Columbia University. Marine naturally occurring compounds that contain basic nitrogen atoms (alkaloids) will be synthesized. Some of the alkaloids to be synthesized are neurotoxins which are found in red-tides. In the course of this research it is anticipated that new synthetic methods will be developed as well as shorter routes to the naturally occurring alkaloids. Related compounds that will be synthesized have potentially interesting medicinal properties.