Dienophilicity of Indole and Pyrrole in Inverse Electron Demand Diels-Alder Reactions; Exploration and Synthetic Applications

本研究的重点是综合方法学的发展 使用反电子需求Diels-Alder环加成， 和吡咯作为亲二烯体。 该方法的目标包括 Aspidosperma生物碱，β-咔啉，咔唑生物碱和 吲哚生物碱的氮杂吲哚类似物。 有了这个奖项，合成 有机计划是支持博士的研究。斯奈德的 波士顿大学化学系。 斯奈德教授将 他的工作重点是使用环加成方法进行合成 具有有趣生物学特性的生物碱天然产物

The focus of this research is the development of synthetic methodology using inverse electron demand Diels-Alder cycloadditions utilizing indole and pyrrole as dienophiles. Targets of the methodology include Aspidosperma alkaloids, beta-carbolines, carbazole alkaloids and azaindole analogues of indole alkaloids. With this award, the Synthetic Organic Program is supporting the research of Dr. John K. Snyder of the Department of Chemistry at Boston University. Professor Snyder will focus his work on the use of cycloaddition methodology for the synthesis of alkaloid natural products that have interesting biological properties