alpha-Silylketone Enolates: Precursors in the Preparation of Diols, Aminoalcohols, Alcohols, and Amines

这是格林内尔学院Mader教授的有机合成程序中的RPG，将用于详细说明α硅酮烯醇酯的合成潜力。二醇、氨基醇、醇和胺的制备模型系统将是最初的目标。随后的研究将尝试加入手性助剂，从而产生上述类型底物的手性类似物。使用选择性试剂合成有机化合物的能力是一种非常重要的方法。在这个提议中，PI不仅计划更有效地制造化合物，而且还计划将它们制备成它们的光学类似物。这对于药品生产和其他工业过程是非常重要的。

This RPG in the Organic Synthesis Program to Professor Mader of Grinnell College will be used to elaborate the synthetic potential of alpha silylketone enolates. Model systems for the preparations of diols, aminoalcohols, alcohols and amines will be the initial targets. Subsequent studies will attempt to incorporate chiral auxiliaries thereby generating the chiral analogues to the above types of substrates. The ability to synthesize organic compounds using selective reagents is a very significant methodology. In this proposal not only is the PI planning to make compounds more efficiently, but also to prepare them as their optical analogues. This is very significant regarding drug manufacturing and other industrial processes.