U.S. Japan Seminar: Molecular Dynamics of Ligand Binding to Myoglobins and Related Heme Proteins

该奖项支持15名美国科学家参加于1997年3月2日至5日在德克萨斯州休斯敦莱斯大学举行的题为“肌红蛋白和相关血红素蛋白的配体结合分子动力学”的美日研讨会。协办方是莱斯大学的John S. Olson教授和日本冈崎国立研究所分子科学研究所的Teizo Kitagawa教授。研讨会的具体目的是：(1)总结目前在将计算机模拟与氧、一氧化碳和一氧化氮与肌红蛋白和血红蛋白结合的动力学测量相关联方面取得的成功；(2)确定与将计算和结构确定扩展到生理学重要时间尺度（纳米到毫秒）相关的关键问题；(3)提出解决这些问题的新方法及其与血红素蛋白血液替代品设计的关系。长期目标是在日本和美国领先的科学家之间建立联合研究项目，这将进一步推动计算，蛋白质工程和时间分辨光谱技术的极限，并将通过国际合作的科学知识交流和转移来实现美国/日本计划的目标。＊＊＊

9513084 Olson This award supports the participation of 15 U.S. scientists in a U.S.-Japan seminar entitled "Molecular Dynamics of Ligand Binding to Myoglobins and Related Heme Proteins" to be held at Rice University in Houston, Texas on March 2-5, 1997. The co-organizers are Professor John S. Olson from Rice University and Professor Teizo Kitagawa from the Institute for Molecular Science, Okazaki National Research Institutes, Japan. The specific aims of the seminar are to: (1) summarize current successes in correlating computer simulations with kinetic measurements of oxygen, carbon monoxide, and nitric oxide binding to myoglobins and hemoglobins; (2) identify key problems associated with extending computations and structure determinations to physiologically important time scales (nano- to milliseconds); and (3) propose new approaches to address these issues and their relationship to the design of heme protein-based blood substitutes. The long-term goals are to create joint research programs between a cross section of leading Japanese and American scientists which will push further the limits of computational, protein engineering, and time-resolved spectroscopic techniques, and which will fulfill the objectives of the U.S./Japan Program through the exchange and transfer of scientific knowledge by international collaboration. ***