Investigations of Macrocycles of Plant Origin

本研究的重点是环肽生物碱和丁类化合物的制备。将发展13、14和16元环体系的合成方法，并比较引入酰胺键的新方法。大环化的各个方面将被检查，包括假脯氨酸结合到分子的关键位点。此外，将对产品进行光谱研究，以探测分子与金属阳离子结合的能力。有了这个更新奖，合成有机项目支持宾夕法尼亚大学化学系的Madeleine M. Joullie博士的研究。朱丽教授将专注于合成一系列环肽生物碱，这些生物碱具有有趣的生物和物理特性。

The focus of this research is the preparation of cyclopeptide alkaloids and astins. Methodology for the synthesis of 13, 14, and 16 membered ring systems will be developed and new ways of introducing the enamide bond will be compared. Various aspects of macrocyclization will be examined including the incorporation of psuedo-prolines into key sites in the molecules. Also, spectroscopic studies of the products will be carried out to probe the ability of the molecules to bind to metal cations. With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Madeleine M. Joullie of the Department of Chemistry at the University of Pennsylvania. Professor Joullie will focus her work on the synthesis of a series of cyclopeptide alkaloids that possess interesting biological and physical properties.