Pore Engineering of Chromatography Membranes for Bioseparation

蛋白质分离和纯化是治疗性蛋白质生产过程中的重要单元操作。该项目旨在通过定制膜孔几何形状和表面功能来提高分离性能，从而推进色谱膜的实际应用，这是一种新兴的蛋白质分离和纯化技术。该项目旨在产生反应性聚合物合成，功能膜制造和生物分离应用领域的先进知识和技术。该项目开发的创新膜能够提高治疗性蛋白质制造工艺的生产能力，为澳大利亚带来显著的经济效益。

Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and techniques in the fields of reactive polymer synthesis, functional membrane fabrication and application in bioseparation. The innovative membranes developed in the project are able to improve the production capacity of therapeutic protein manufacturing processes, providing significant economic benefits to Australia.