U.S.-French Cooperative Research: Structural and Functional Studies of Inhibition of Acetylcholinesterase by Fasciculin

这项为期三年的美法结构生物学合作研究奖的参与者包括加州大学圣地亚哥分校的帕尔默·泰勒和法国马赛艾克斯第二大学的帕斯卡尔·马尔霍。他们的研究目的是研究乙酰胆碱酯酶（AChE）与其神经毒素、抑制剂束状蛋白2的相互作用。他们建议获得一个脱酶晶体，并分析酶-毒素相互作用的动力学。该项目利用了美国和法国研究人员的互补专业知识，并提供了进入法国同步加速器设施的机会。它将促进我们对酶和毒素之间相互作用模式的理解。

This three-year award for U.S.-France cooperative research in structural biology involves Palmer Taylor of the University of California at San Diego and Pascale Marchot of the University of Aix Marseille II in Marseille, France. The objective of their research is to investigate the interaction of the enzyme acetylcholinesterase (AChE) and its neurotoxin, inhibitor fasciculin 2. They propose to obtain a crystal of the apoenzyme and analyze the kinetics of the enzyme-toxin interaction. The project takes advantage of complementary expertise of the U.S. and French investigators and provides access to synchrotron facilities in France. It will advance our understanding of the mode of interaction between enzymes and toxins.