RUI: Arabidopsis Type 2A Protein Phosphatase Regulatory Subunit B

[603782] Rundle这项工作将研究拟南芥蛋白磷酸酶2A亚型。这个磷酸酶家族参与了植物的许多发育过程，并参与了环境信号的感知和信号转导。在植物中对这些蛋白质的研究还不多，到目前为止，主要的重点都放在了相应的蛋白激酶上。这项工作将利用保守区域来扩增磷酸酶，将研究家族成员的基因组组织，表征转录本，检查它们的细胞定位，并致力于蛋白质表达和分析系统。这些都是这位年轻研究者的长期目标。更短期的目标包括培养本科生和建立实验体系。由于PP2A家族蛋白在植物与环境相互作用中的关键作用，目前在植物中受到越来越多的关注，因此这项工作是及时的，值得系统的研究。

9603782 Rundle The work will investigate protein phosphatase 2A isoforms in Arabidopsis thaliana. This family of phosphatases is involved in a number of developmental processes in plants and in the sensing and signal transduction of environmental cues. Not much work has been focused on these proteins in plants - major emphasis has up to now been given to the corresponding protein kinases. The work will utilize conserved regions to amplify the phosphatases, will study the genomic organization of family members, characterize transcripts, examine their cellular localization, and work towards a protein expression and analysis system. These are long-range goals for this young investigator. More short term objectives include the training of undergraduate students and setting up the experimental system. The PP2A family is receiving more attention at the moment in plants because of the pivotal role of the proteins in plant environment interactions, making such work timely and worthy of systematic investigations.