Transcutaneous Laser Doppler Measurement of Mucus Clearance

9704180清除Yamashiro粘液是肺部疾病如囊性纤维化患者面临的主要问题。 由于缺乏可靠的非侵入性测量气道粘液清除率的方法，用于增强粘液清除的有效疗法和辅助装置的开发受到很大阻碍。 目前，由于缺乏这种能力，药物剂量、辅助装置和物理治疗策略不能针对特定患者进行优化。 这种情况类似于试图在没有定期血压测量的情况下治疗高血压。 提出了一种非侵入性经皮（通过皮肤）激光多普勒方法，其中低功率激光束被引导到颈部区域的气道中以测量移动粘液层的速度。 将开发信号处理技术，以区分皮肤和组织的粘液层反射。将使用粘液流动和组织灌注的机械模型进行初步评价。*

9704180YamashiroMucus elimination is a major problem faced by patients with lung diseases such as cystic fibrosis. Development of effective therapies and assist devices for enhancing mucus removal is greatly hindered by the lack of a reliable non-invasive method of measuring mucus clearance in the airways. Currently, drug doses, assist devices, and physical therapy strategies cannot be optimized for a particular patient due to the lack of this capability. The situation is analogous to trying to treat hypertension without periodic blood pressure measurements. A non-invasive transcutaneous (through the skin) laser doppler method is proposed where a low power laser beam is directed into the airway in the neck region to measure the velocity of the moving mucus layer. Signal processing techniques will be developed to discriminate mucus layer reflections from those from skin and tissue. Initial evaluation will be made using a mechanical model of mucus flow and tissue perfusion.***