CAREER: Direct Measurement and Mathematical Analysis of Receptor-Mediated Bacterial Attachment on Biomaterial Surfaces

9704236迪金森PI建议在生物工程开发一个综合的研究和教育计划。 研究部分涉及研究细菌粘附到表面的机制，这是植入器械感染发展的关键早期步骤。 将使用全内反射显微镜和三维激光光捕获测量金黄色葡萄球菌与表面的非特异性（胶体型）和受体介导的相互作用。 力和附着动力学将用于开发细菌附着的机械数学模型。 ambitimus教育计划包括参与生物医学工程研究生，多学科学位课程和生物化学工程本科学位课程的发展。 PI将通过在这两个领域开发新的课程和实验室课程来参与。 ***

9704236 Dickinson The PI proposes to develop an integrated research and educational plan in bioengineering. The research component involves a study of the mechanism of bacterial adhesion to surfaces, a key early step in the development of infections on implant devices. Non-specific (colloidal-type) and receptor-mediated interactions of Staphylococcus aureus to surfaces will be measured using total internal reflection microscopy and three dimensional laser optical trapping. The forces and attachment kinetics will be used to develop a mechanistic mathematical model for bacterial attachment. The ambitimus educational plan involves participation in the development of a graduate, multi-disciplinary degree program in biomedical engineering and an undergraduate degree program in biochemical engineering. The PI will participate by developing new class and laboratory courses in both areas. ***