Behavioral Correlates of CNS Sprouting

建议编号：IBN-9722829大脑中对学习和记忆非常重要的两个区域是海马体和内嗅皮层。当海马体失去与内嗅皮层的连接时，例如由于大脑的损伤，记忆功能会受损，但在损伤后两周内就会恢复。损伤后，内嗅皮层的剩余区域和其他大脑区域会长出新的连接到海马体。这个项目研究了这些新的连接如何协同工作，以调节大脑的代偿性变化，并促进记忆功能的恢复。该项目阐明了参与学习和记忆的不同大脑区域是如何协同工作的，以及它们在损伤后如何相互作用来补偿这种损伤。除了这些具体的贡献外，该项目还提供了关于大脑结构重组能力以及这种重组如何导致功能变化的基本信息。

Lay Abstract PI: Ramirez, Julio J. Proposal Number: IBN-9722829 Two areas of the brain that are very important for learning and memory are the hippocampus and the entorhinal cortex. When the hippocampus is deprived of its connections with the entorhinal cortex, for example as a result of injury to the brain, memory functions become impaired but recover within two weeks after the injury. After injury, remaining areas of the entorhinal cortex and other brain areas grow new connections to the hippocampus. This project examines how these new connections work together to mediate compensatory changes in the brain and to promote the recovery of memory functions. The project clarifies how different brain regions involved in learning and memory work together and how they interact following damage to compensate for that damage. In addition to these specific contributions, the project provides fundamental information about the capacity of brain structures to reorganize and how such reorganization leads to changes in function.