SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing

CRC870《神经元电路的组装和功能》的目标是通过研究神经元电路、它们的组装、动力学和信号处理，在明确允许假设驱动的方法的水平上，弥合分子和细胞过程的机械理解与更高的大脑功能之间的差距。CRC最初专注于结构-功能关系和计算建模，自我约束到感觉处理的早期阶段潜在的电路。在成功的第一个资助期的基础上，儿童权利委员会扩大了其范围，纳入了与运动系统的感觉交互作用。此外，一方面与发育、再生和可塑性有关的项目(A组)和另一方面与功能更相关的项目(B组)通过CRC中的主要问题进一步联系在一起：1)可塑性和再生，2)感觉-运动相互作用，3)动作电位产生原理，轴突功能和髓鞘形成。最后，开发新工具和方法并提供技术支持的中央项目(Z组)得到了加强，并大大促进了儿童权利委员会的产出。第二个资助期的成功体现在许多出版物上，这些出版物的作者来自一个以上的子项目；与第一个资助期相比，出版物的数量增加了一倍多(自2014年以来为110个，总共为170个)，高影响力的出版物所占比例很高(约三分之一有影响因素)，最重要的是，通过大量的个人互动和不断增加的内部动力。首先，基于与发育、再生和可塑性(例如活动)的共同原则相关的结果，许多项目将处理电路动力学和修复(例如损伤后)的问题。其次，潜在可量化行为的电路动力学将成为CRC870子项目中越来越多比例的焦点，这反映在一个新的桥梁主题4)电路动力学潜在行为中。CRC范围的扩大将在假设驱动的原则下实现，该原则是对具有明确可识别功能的感觉和马达电路进行研究。CRC870成为一个重要的本地枢纽，与慕尼黑伯恩斯坦计算神经科学中心(BCCN)、卓越集群系统神经学(Synergy)、新的研究培训小组(RTG)2175环境感知和系统神经科学研究生院(GSNLMU)密切互动。CRC870大大加强了与局部网络内神经元电路组装和功能相关的研究和教学。

The goal of the CRC 870 Assembly and Function of Neuronal Circuits is to bridge the gap between the mechanistic understanding of molecular and cellular processes and higher brain functions by studying neuronal circuits, their assembly, dynamics, and signal processing at a level that explicitly allows for hypothesis driven approaches. Focusing on the structure-function relationship and computational modeling, the CRC originally self-restrained itself to circuits underlying early stages of sensory processing. Building on a successful first funding period the CRC widened its scope by including sensory interactions with motor systems. Moreover, the projects related to questions of development, regeneration and plasticity on the one hand (cluster A) and the more function related projects on the other hand (cluster B) have been further linked through overarching questions across the CRC: 1) Plasticity and Regeneration, 2) Sensory-Motor Interactions, 3) Principles Action Potential Generation, Axon Function and Myelination. Finally, the central projects (cluster Z) that develop new tools and methods and provide technical support were strengthened and contributed substantially to the CRC’s output. The success of the second funding period manifests itself by numerous publications with authors from more than one sub-project, by the fact that the number of publications more than doubled compared to the first funding period (>110 since 2014, >170 altogether), by the high proportion of high-impact publications (about one third with impact factors >10) and, most importantly, by numerous personal interactions and constantly increasing internal dynamics.For the third funding period a careful but strategic widening of the scope of CRC 870 has been planned. Firstly, building on the results related to common principles of development, regeneration and plasticity (e.g. activity), many projects will deal with questions of circuit dynamics and repair (e.g. after injury). Secondly, circuit dynamics underlying quantifiable behavior will move into the focus of an increasing proportion of CRC 870 sub-projects, reflected in a new bridging topic 4) Circuit Dynamics Underlying Behavior. This widening of the CRC’s scope will be realized within the principle of hypothesis driven research on sensory and motor circuits with clearly identifiable functions. These developments will be implemented without increasing the number of projects and without significant increase of the overall budget.The CRC 870 became an important local hub with intense interactions with the Munich Bernstein Center for Computational Neurosciences (BCCN), the Excellence Cluster Systems Neurology (SyNergy), the new Research Training Group (RTG) 2175 Perception in Context, and the Graduate School of Systemic Neurosciences (GSNLMU). The CRC 870 significantly strengthened research and teaching related to neuronal circuit assembly and function within the local networks.