Coordination and Modulation of a Reflex Motor Pattern

摘要PI: Trimmer， Barry A.提案号：IBN-9723507本研究的目的是了解反射运动如何被修改和适应不同的任务，使它们适合不同的行为。详细的运动分析与不同训练前后肌肉的电记录相结合。一旦这些变化被描述，通过记录单个神经细胞的电活动，以及在行为训练和感觉刺激期间操纵这些神经细胞上的化学受体，来研究介导这些变化的中枢神经系统机制。这项研究将行为的适应性变化与学习和可塑性背后的细胞机制联系起来。它的结果有助于理解基本的有节奏的运动，如走路，是如何根据经验进行修改的，以便在各种情况和挑战中适当地表达这种行为。

Lay Abstract PI: Trimmer, Barry A. Proposal Number: IBN-9723507 The objective of this research is to understand how reflex movements are modified and adapted for different tasks so that they are appropriate for different behaviors. Detailed analysis of movement is combined with electrical recordings from muscles both before and after different training regimes. Once the changes are described, the central nervous system mechanisms that mediate these changes are investigated by recording the electrical activity of individual nerve cells and by manipulating the chemical receptors on those nerve cells during behavioral training and during sensory stimulation. This research links adaptive changes in behavior with the cellular mechanisms underlying learning and plasticity. Its results contribute to understanding how basic rhythmic movements, such as those involved in walking, are modified as a result of experience so that the behavior can be appropriately expressed in a variety of situations and challenges.