Effects of Progressive Periods of Cholinergic Depletion on Brain and Behavior.

简单摘要 主要研究者：Harris-Warrick，罗纳德提案编号： IBN-9728553 这次关于产生运动活动的神经机制的国际会议是在纽约科学院的赞助下于1998年3月21日至24日在纽约市举行的。会议的主要重点是讨论高等脊椎动物（包括人类）运动神经元基础的新研究。作为介绍性概述，介绍了最好理解的脊椎动物和无脊椎动物的准备工作，然后是高等脊椎动物的脊髓运动网络会议。第二天重点介绍了模式生成网络的神经递质控制，这些生成器的感官输入，充分理解的网络建模，以及理解神经网络功能和调制的分子生物学方法。在最后一天，会议涵盖了各种发展和比较的方法来研究动物和人类的节奏运动和脊髓运动网络分析的临床应用。最后一个小组讨论负责产生节奏模式生成的一般原则和讨论未来研究的富有成效的途径。 简单摘要 主要研究者：Herron，Paul提案编号： IBN-9729545 胆碱能耗竭进行性阶段对脑和行为的影响 脑神经递质乙酰胆碱被认为在大脑对感觉和认知体验的适应性反应中起主要作用。本研究的目的是确定选择性消耗乙酰胆碱对大脑结构，功能和行为的影响。这项研究将使人们能够了解乙酰胆碱对大脑皮层神经回路和突触数量的作用;皮层单个神经元的神经活动;以及学习和记忆的机制。结果显示，当乙酰胆碱不存在于一定水平时，大脑结构、大脑功能和行为是如何退化的。这项工作对于更好地理解乙酰胆碱在感觉知觉以及学习和记忆中的适应和维持作用非常重要。

LAY ABSTRACT Principal Investigator: Harris-Warrick, Ronald Proposal Number: IBN-9728553 This international conference on the neural mechanisms for generating locomotor activity is held under the auspices of the New York Academy of sciences in New York City on March 21-24, 1998. The primary focus of the conference is to discuss new research on the neuronal basis for locomotion in higher vertebrates, including man. As an introductory overview, the best understood vertebrate and invertebrate preparations are presented , followed by a session on spinal locomotor networks in higher vertebrates. The second day highlights sessions on neurotransmitter control of pattern generating networks, sensory inputs to these generators, modeling of well understood networks, and molecular biological approaches to understanding neural network function and modulation. On the final day, the sessions cover various developmental and comparative approaches to study rhythmic locomotion and clinical applications of spinal locomotor network analysis in animals and man. A final panel discussion is charged with generating general principles for rhythmic pattern generation and discussion of fruitful avenues for future research. LAY ABSTRACT Principal Investigator: Herron, Paul Proposal Number: IBN-9729545 Effects of Progressive Periods of Cholinergic Depletion on Brain and Behavior The brain neurotransmitter, acetylcholine, has been suggested to play a major role in the adaptive response of the brain to sensory and cognitive experiences. The purpose of this research is to determine the consequences of selective depletion of acetylcholine on brain structure, function, and behavior. This research will enable an understanding of the role of acetylcholine on the underlying brain circuitry and quantity of synapses in the cortex; the neural activity of single neurons in the cortex; and the mechanism of learning and memory. Results show how brain structure, brain function and behavior are degraded when acetylcholine is not present at certain levels. This work is important for providing a better understanding of the adaptive and maintenance roles of acetylcholine in sensory perception as well as learning and memory.