Postdoctoral Research Fellowship in Biosciences Related to the Environment for FY 1997

摘要DBI 9750196香农·斯塔尔这一行动资助了美国国家科学基金会1997年与环境相关的生物科学博士后研究奖学金。这一奖学金为研究员提供了一个在博士学位之外获得额外科学培训的机会，并在任何生物领域的分子、细胞、组织、种群、社区和/或生态系统层面上以创新和富有想象力的方式探索生物体与其环境之间相互作用的基本机制，这一领域得到了国家科学基金会生物科学局的支持。每个研究金资助一项研究和培训计划，该计划将在一个赞助实验室进行。该奖学金的研究和培训计划名为“甲烷单加氧酶的研究”，这是一种对石油泄漏清理和温室气体消耗非常重要的酶。甲烷单加氧酶(MMO)催化甲烷好氧氧化制甲醇，对从全球变暖到生物修复等环境问题具有重要意义。这项研究使用了从动力学同位素效应研究到定点突变的各种方法来研究MMO激活氧气和底物氧化的机制。

Abstract DBI 9750196 Shannon Stahl This action funds an NSF Postdoctoral Research Fellowship in Biosciences Related to the Environment for 1997. This fellowship provides an opportunity for the Fellow to gain additional scientific training beyond the doctoral degree and to pursue innovative and imaginative into the fundamental mechanisms underlying the interactions between organisms and their environment at the molecular, cellular, organismal, population, community and/or ecosystem level in any area of biology supported by the Directorate for Biological Sciences of the National Science Foundation. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled "Studies of methane monooxygenase, an enzyme important for oil spill cleanup and greenhouse gas depletion." Methane monooxygenase (MMO) catalyzes the aerobic oxidation of methane to methanol and has important implications for environmental issues ranging from global warming to bioremediation. This research examines the mechanism of dioxygen activation and substrate oxidation by MMO using various methods ranging from kinetic isotope effect studies to site-directed mutagenesis.