POWRE: Modeling Trabecular Bone Adaptation to Mechanical Engineering

9753164范德梅伦力学在骨骼的生长、发育和适应中起着重要的作用。骨组织是一种对其机械环境作出反应和适应的有生命的材料。本研究将探讨机械载荷对骨小梁适应性的影响。小梁骨是一种各向异性的低密度骨。康奈尔大学医学中心附属的特殊外科医院开发了一种动物小梁骨适应模型。压缩力将应用于成年兔的股骨远端，并将确定小梁结构的变化。本研究的目的是对这些适应实验进行建模和模拟。实验的有限元模型将由检索到的标本的三维微计算机断层扫描图像创建。从这些模型中，将确定局部加载条件并将其与小梁骨适应相关联。然后利用该模型模拟小梁对载荷的适应性。这些适应模型是荷兰奈梅亨天主教大学开发的适应框架的首次应用；该模型应用程序将与奈梅亨的一名研究人员合作。目标是了解骨功能适应在许多骨骼疾病的病因学中很重要，包括骨质疏松症和骨关节炎。＊＊＊

9753164 van der Meulen Mechanics plays an important role in the growth, development and adaptation of the skeleton. Bone tissue is a living material which responds and adapts to its mechanical environment. This research will examine the influence of mechanical loading on trabecular bone adaptation. Trabecular bone is the anisotropic low density bone. An animal model of trabecular bone adaptation has been developed at The Hospital for Special Surgery, an affiliate of Cornell University Medical Center. Compressive forces will be applied to the distal femur of adult rabbits and the resulting changes in trabecular architecture will be determined. The objective of this study is to model and simulate these adaptation experiments. Finite element models of the experiments will be created from three- dimensional micro-computed tomography images of the retrieved specimens. From these models, the local loading conditions will be determined and correlated with trabecular bone adaptation. Then the models will be used to simulate the trabecular functional adaptation to the applied loading. The adaptation models are the first application of an adaptation framework developed at the Katholieke Universiteit, Nijmegen, the Netherlands; the model application will be in collaboration with an investigator in Nijmegen. The goal is to acquire an understanding of bone functional adaptation important in the etiology of many skeletal disorders, including osteoporosis and osteoarthritis. ***