Immune responses to native and artificial extracellular matrices (B03)

J. Simon和S. Franz已经确定了GAG衍生物免疫调节的重要机制。他们在第三个资助期的目标是研究适应伤口愈合不同阶段的多功能水凝胶（例如，抗炎和促进再生功能的组合）。它还计划评估基于sHA的水凝胶如何终止慢性伤口的炎症。在转化方法中，将使用来自患有受损伤口愈合的患者的伤口流体和巨噬细胞来验证aECM的免疫调节作用。

J. Simon and S. Franz have identified important mechanisms of immune modulation by GAG derivatives. Their aim in the third funding period is to investigate multifunctional hydrogels adapted to the different phases of wound healing (e.g. combination of anti-inflammatory and regeneration-promoting functions). It also planned to evaluate how sHA-based hydrogels terminate inflammation in chronic wounds. In a translational approach, the immunomodulatory effects of aECM will be validated using wound fluids and macrophages from patients suffering from impaired wound healing.