Host-Parasite Coevolution: Programme coordination an meta-analysis of Host-Parasite Coevolution

1399年优先方案“宿主-寄生虫共同进化”的主要目标是建立宿主-寄生虫共同进化，作为分析进化适应的原因和过程的一个强大和通用的模型。该优先方案预计将整合德国境内迄今孤立的研究工作。在一个优先规划内进行更大规模、协调一致的研究的机会将使我们能够揭示宿主-寄生虫共同进化过程中进化变化的分子基础。这就需要包括具有非常多样化专业知识的研究人员，例如进化生物学、寄生虫学和微生物学。此外，将从许多不同种类的宿主和寄生虫中获取数据，而不是只研究一种模式生物。因此，这种方案的成功在很大程度上取决于方案内以及与国际研究人员进行沟通、数据交换和协调的良好工具。虽然每个研究生物的主要数据和具体结论将由个别项目提供，但需要对预期结果进行中央荟萃分析，以确定一般模式并将其与特定物种区分开来。基于这样的荟萃分析，一般模式和过程的建模将允许实现宿主-寄生虫共同进化过程的预测框架。为此目的，要求为本优先方案内的通讯和协调系统以及中央综合分析和建模提供资金。

The main goal of the priority programme 1399 “Host-Parasite Coevolution” is to establish host-parasite coevolution as a powerful and versatile model for analyzing the causes and processes of evolutionary adaptation. The priority programme is expected to integrate as yet isolated research efforts within Germany. The opportunity for larger, concerted research within a priority programme will enable to uncover the molecular basis of evolutionary change during host-parasite coevolution. This requires that researchers with very diverse expertise, such as evolutionary biology, parasitology and microbiology, will be included. Moreover, rather than working on just one model organism, data will be acquired from many different species of hosts and parasites. The success of such a programme thus critically relies on excellent tools for communication, data exchange and coordination within the programme and with international researchers. While primary data and specific conclusions for each study organism will be provided by the individual projects, a central meta-analysis of the expected results is required to identify general patterns and to distinguish them from species-specific ones. Based on such a meta-analysis, modelling of general patterns and processes will allow achieving a predictive framework for host-parasite coevolutionary processes. For that purpose, funding for a communication and coordination system within this priority programme and for central meta-analysis and modelling is requested.