POWRE: Sulfate Transport in Proximal Tubule Epithelial Cells

莫里斯博士的长期目标是了解(在肾脏和其他组织中)硫酸盐稳态的荷尔蒙和非荷尔蒙调节。孕妇的血清硫酸盐浓度升高，胎儿和幼儿的血清硫酸盐浓度高于成人。肾转运改变的机制尚不清楚。这项POWRE奖将支持探索性工作，以确定使用人和大鼠近端小管细胞原代培养系统和人类近端小管细胞系来评估调节肾脏硫酸盐运输的因素的可行性。

Dr. Morris' long-term goal is to understand the hormonal and nonhormonal regulation of sulfate homeostasis (in the kidney and in other tissues). Serum concentrations of sulfate are increased in pregnant women and are higher in the fetus and young children than in adults. The mechanisms for the alterations in renal transport are not known. This POWRE award will support exploratory work to determine the feasibility of using human and rat proximal tubule cell primary culture systems and a human proximal tubule cell line for the evaluation of factors that regulate renal sulfate transport.