Career: Invention and Development of 'Tin-Lite' Reactions for Organic Synthesis

本研究的重点是开发“锡-轻质”替代有机锡化学的反应。将开发一种实用的锡催化的Stille交叉偶联反应，该方法也将应用于传统的有机锡介导的反应、铜基交叉偶联氟相反应和组合化学。这一结果可能会对生物重要化合物的商业合成产生广泛影响。该项目的教育部分包括向高中生介绍有意义的实验室经验，并在本科生水平上引入药物化学课程。有了这个职业奖项，有机和高分子化学计划正在支持Robert E.密歇根州立大学化学系的马莱茨卡说。Maleczka教授将专注于锡烷催化反应在有机合成中的发现、开发和应用，具体目标是将这些反应中的锡需求降至最低。该方法将依赖于设计在锡中催化的新反应，并寻找非锡替代品。该方法对制药业的合成具有广泛的意义。该项目的教育活动包括课程开发和高中外展。

The focus of this research is the development of "Tin-Lite"alternatives to reactions involving organotin chemistry. A practical, tin catalyzed Stille cross-coupling reaction will be developed and the methodology will also be applied to traditional organotin mediated reactions, copper based cross-couplings fluorous phase reactions and combinatorial chemistry. The results could have a broad impact on the commercial synthesis of biologically important compounds. The educational component of the project involves the introduction of high school students to a meaningful laboratory experience and the introduction of a pharmaceutical chemistry course at the undergraduate level.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Robert E.. Maleczka of the Department of Chemistry at Michigan State University. Professor Maleczka will focus his research on the discovery, development and application of stannane mediated reactions in organic synthesis with the specific goal of minimizing the tin requirement in these reactions. The approach will rely on the design of new reactions catalytic in tin and in seeking non-tin alternatives. The methodology has broad implications for synthesis in the pharmaceutical industry. The educational activities of the project include curriculum development and high school outreach.