NANOSCALE: Nanostructured Biocomposites for Use as Novel Films and Coatings

摘要提案编号：CTS-9986488提案类型：对NSF 99-109《纳米尺度生物系统探索性研究》的回应首席研究员：James F. RathmanAffiliation： 俄亥俄州国家纳米尺度：作为新型薄膜和涂层使用的纳米结构生物复合材料本探索项目研究含有有机和无机成分的纳米结构复合薄膜的制造和应用，特别是由二氧化硅基质组成并含有胶原蛋白和纤维连接蛋白的薄膜。 该膜在液-液界面处合成，并且表面活性剂用于促进具有有用性质的自组装和纳米结构。 将测试新型薄膜的三种应用。 纳米多孔二氧化硅-胶原蛋白膜有望具有良好的热稳定性和机械强度。 它们将作为保护涂层进行测试，以防止有机电致发光显示器件的潮湿损坏。胶原蛋白-二氧化硅复合材料的纤连蛋白修饰将作为稳定分子筛的来源进行测试，并且将控制孔径以提供可以从生物工艺流中过滤病毒的膜。 此外，纤连蛋白系链的能力将在微载体中用于含有贴壁依赖性细胞的细胞培养物。 成功地实现这些独特的复合材料的新特性可以导致各种各样的应用。

AbstractProposal number: CTS-9986488Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: James F. RathmanAffiliation: Ohio State NANOSCALE: Nanostructured Biocomposites for Use as Novel Films and Coatings This exploratory project investigates the fabrication and applications of nanostructured composite films containing both organic and inorganic components, specifically films consisting of a silica matrix and containing collagen and fibronectin. The films are synthesized at a liquid-liquid interface, and surfactants are used to promote self-assembly and nanostructures with useful properties. Three applications of the new types of films will be tested. Nanoporous silica-collagen films are expected to have good thermal stability and mechanical strength. They will be tested as protective coatings to prevent moisture damage of organic electroluminescent display devices. Fibronectin modification of collagen-silica composites will be tested as a source of stable molecular sieves, and the pore sizes will be controlled to provide membranes that can filter viruses from bioprocess streams. Also, the ability of fibronectin tethers will be exploited in microcarriers for cell cultures containing anchorage-dependent cells. Success in achieving novel properties with these unique composites can lead to a wide variety of applications.