US-Egypt Cooperative Research: Utilization of Keratin-Containing Materials by Recombinant Bacteria

描述：该奖项是为了支持由亚特兰大佐治亚州立大学生物学教授兼艺术与科学学院院长Ahmed T.Abdelal博士和埃及亚历山大市亚历山大市大学研究生院生物科学与技术系Taha I.扎格卢尔博士共同开展的一个项目。他们计划研究利用重组DNA技术来提高蛋白水解酶的生产，这是有效利用各种环境废物所必需的。他们还计划开发有效的蛋白水解酶的纯化程序，并从底物专一性和最佳条件方面对纯化的酶进行表征。被检测的材料包括羽毛、头发、羊毛和指甲等含有角蛋白的材料，这些材料含有丰富的蛋白质和碳源。范围：美国调查人员Abdelal博士因其科学和学术成就以及在微生物学和DNA研究方面的专业知识而受到认可。埃及合作者扎格卢尔博士取得了重大科学成就，并与美国和英国该领域的研究人员建立了良好的科学联系，他在英国进行了初步调查，为该项目提供了支持。双方拥有互补的能力和实验室设施。该项目将对美国和埃及在增加这一微生物学领域以及农业和工业废物环境处理方面的科学知识方面具有重大价值。亚历山大大学的研究生将参与这项研究，他们将在佐治亚州立大学短期工作。这一建议符合INT支持在共同感兴趣的领域进行合作研究的目标。该项目得到了美国-埃及联合基金计划的支持，该计划为两国的科学家和工程师提供资助，以开展这些合作活动。

0001562AbdelalDescription: This award is to support a collaborative project by Dr. Ahmed T. Abdelal, Professor of Biology and Dean, College of Arts and Sciences, Georgia State University, Atlanta, and Dr. Taha I. Zaghloul, Department of Biosciences and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. They plan to study the utilization of recombinant DNA technology to enhance the production of proteolytic enzymes, which are required for efficient utilization of a wide range of environmental waste materials. They also plan to develop efficient purification procedures for the proteolytic enzymes, and to characterize the purified enzymes with respect to substrate specificity and optimal conditions. The materials to be tested include keratin-containing materials such as feathers, hair, wool, and nails, which are rich in protein and carbon sources. Scope: The US Investigator, Dr. Abdelal, is recognized for his scientific and academic accomplishments and for his expertise in microbiology and in DNA research. Dr. Zaghloul, the Egyptian collaborator, has major scientific accomplishments and is well connected scientifically with researchers in the field in the USA and also in the United Kingdom where he has done preliminary investigations that will support this project. The two sides have complementary capabilities and laboratory facilities. The project will have significant value to the United States and Egypt both in increasing the scientific knowledge in this area of microbiology and in the environmental treatments of agricultural and industrial wastes. Graduate students at the University of Alexandria will participate in the research, working for short periods at Georgia State University. This proposal meets the INT objective of supporting collaborative research in areas of mutual interest. This project is being supported under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to carry out these cooperative activities.