SenseLab: Integration of Multidisciplinary Sensory Data

这个项目的总体目标，包括三个研究组成部分，是利用该研究小组之前的工作，包括SenseLab，开发一套神经信息学工具，以支持嗅觉系统功能组织的分析。其根本原因是，在脑功能分析中，实验数据的产生目前超过了对这些数据进行归档、分析和整合的手段。项目1的目的是了解嗅觉感知背后的神经操作的分子序列；为此，该项目将开发4个数据库。项目2将进行必要的信息学研究，以支持其他两个项目，并将结果转移到实际应用的编程核心。项目3将使用已开发数据库中的数据来构建和验证嗅觉系统中相互作用神经元的模型。一个主要的焦点将是对嗅球二尖瓣细胞的综合特性的理解。数据库和工具将增强对神经机制的理解。它们可以推广到其他系统，为整合和搜索神经科学数据提供更广泛的工具。这项研究的部分资金来自美国国家科学基金会参与的“人类大脑计划”，该计划是由国会授权的联邦跨部门研究计划，是“大脑十年”计划的一部分。

The overall goal of this Program Project, which embodies three research components, is to capitalize on previous work by this research group, involving SenseLab, to develop a set of neuroinformatics tools for supporting g the analysis of the functional organization of the olfactory system. The underlying rational is that, in the analysis of brain function, the generation of experimental data currently exceeds the means for archiving, analyzing, and integrating these data. The aim of project 1 is to understand the molecular sequences of the neural operations underlying olfactory perception; to this end the project will develop 4 databases. Project 2 will perform the necessary informatics research to support the other two projects and transfer the results to the programming core for practical applications. Project 3 will use data in the developed databases to construct and validate models of interacting neurons in the olfactory system. A main focus will be the understanding of the integrative properties on the mitral cells for the olfactory bulb. The databases and tools will enhance the understanding of neural mechanisms. They will be generalizable to other systems, to provide tools of wider use for integrating and searching neuroscientific data.This research is funded in part by the National Science Foundation through its participation in the Human Brain Project, which is a Federal interagency research initiative, mandated by Congress as part of the "Decade of the Brain".