GOALI: Fundamental Studies into the Mechanism of Product Variability in Pan and Rotating Drum Coating Equipment

摘要提出了对大颗粒间歇包衣进行定量检测的方法。这种化学涂层还可以起到控制颗粒本身释放特定化学物质的速率的作用。在许多重要的工业应用中(例如，制药)，化学过程的可预测性是必不可少的。因此，至关重要的是，每个颗粒都要尽可能均匀地与下一个颗粒包覆。要实现这一目标，从实验室到工厂，通过传统的碰运气的实验序列，是令人沮丧和昂贵的。拟议的努力是通过可扩展的实验和结果的通用建模相结合的方式，建立“滚筒”涂层过程的基本理论。这些实验将确定在哪些条件下涂层将在所研究的样品上均匀。建模技术将借鉴更新理论，并辅之以组件过程的机械表示(如“雪崩”)。高速成像将提供涂层材料随时间的行为的描述。实验室实验将产生的模型将在相关的工业现场(默克、阿尔扎)进行验证。

AbstractIt is proposed to examine and quantify the batch coating of large particles. Such chemical coats may have in addition the role of controlling the rate of release of specified chemicals from the particles themselves. In many important industrial applications (such as pharmaceuticals , for instance), predictability of the chemical process is essential. Thus, it is critical that each particle be coated in as much uniformity with the next one as possible. To accomplish this goal by the traditional hit and miss sequence of experiments, from laboratory to factory floor, is frustrating and expensive. The proposed effort is to establish the basic theory of the "drum"coating process, by a combination of scalable experiments and generic modeling of the results. The experiments will identify those conditions where coating will be uniform across the sample under study. The modeling techniques will be borrowed from renewal theory, supplemented by mechanistic representations of the component processes (such as "avalanching") . High speed imaging will provide a description of the behavior of the coated material over time. The model which will emerge of the laboratory experiments will be verified at the associated industrial sites (Merck, Alza).