NAS Colloquium on Links Between Recombination and Replication: Vital Roles of Recombination; Irvine, California, November 10 - 12, 2000

富尔顿学术讨论会“复制与复制之间的联系：复制的重要作用”将于2000年11月10日至12日在加州尔湾的阿诺德和美宝贝克曼中心举行。与会者将包括遗传学家，生物化学家，物理化学家和分子生物学家。最近在大肠杆菌和酿酒酵母中的例子提供了越来越多的证据，证明重组和复制之间的联系是广泛的。现在很清楚，复制叉经常停滞或断裂，而重组酶通过拯救这些叉来阻止细胞死亡。这些发现对生物学、医学、工业和农业都有重要意义。对重组在DNA损伤修复中的功能的充分理解将提供对细胞分裂、对DNA损伤的多种反应以及限制致癌作用的机制的进一步了解。基因靶向生物技术也可能找到线索。在细菌中，折叠的复制叉的修复对生存能力有显著影响，对其的进一步研究可能为针对细菌感染的治疗提供新的靶点。学术讨论会的目标是促进对DNA重组和复制之间的联系的进一步研究，并提高整个生物医学界的同事和学生对这一发展中领域的认识。为实现这一目标，《国家科学院院刊》将用整整一期的篇幅专门刊登学术讨论会产生的研究报告。

AbstractMCB-0083174FultonThe Colloquium "Links between Recombination and Replication: Vital Roles of Recombination" will be held from Nov. 10-12, 2000, at the Arnold and Mabel Beckman Center in Irvine, California. Attendees will include geneticists, biochemists, physical chemists, and molecular biologists. Recent examples in Escherichia coli and Saccharomyces cerevisiae have provided increasing evidence that links between recombination and replication are widespread. It is now clear that replication forks frequently stall or break, and that recombination enzymes forestall cell death by rescuing those forks. These findings have important implications for biology, medicine, industry and agriculture. A full understanding of the functions of recombination in the repair of damage to DNA will provide further insights into cell division, the multifarious response to DNA damage, and the mechanisms that limit carcinogenesis. Clues may be found as well for the biotechnology of gene targeting. In bacteria, the repair of collapsed replication forks has a dramatic impact on viability, the further study of which may suggest new targets for therapy directed at bacterial infections. The goal of the Colloquium is to stimulate further research on the connections between DNA recombination and replication, and to increase awareness of this developing area among colleagues and students throughout the biomedical community. Toward the achievement of that goal, an entire issue of the Proceedings of the National Academy of Sciences will be devoted to research reports emanating from the Colloquium.