Star Porphyrazines

美国国家科学基金会化学部无机、生物无机和有机金属化学项目支持西北大学化学系Brian Hoffman博士（首席研究员）和英国伦敦帝国理工学院Anthony Barrett（联合首席研究员）对星型卟啉类药物（pzs）的合作研究。具体来说，他们将(i)研究多金属pz和pz多聚体，它们将在金属离子的局部矩之间表现出大环介导的自旋耦合；（ii）检查卟啉组件和金属连接的pz带，其中包含氧化还原可切换传导和/或自旋耦合；（iii）探索金属-卟啉体系在光学肿瘤成像中的造影剂作用；（iv）研究含有活性中心金属离子（例如铁或锰）的带电pzs作为过氧亚硝酸盐分解的可能催化剂；(v)探索卟啉类与外围取代基结合氧化还原活性金属在溶胶-凝胶结合光学传感器和/或双光电/电化学金属离子传感器中的应用。该奖项支持的工作将对各种科学和技术应用产生重大影响。星型卟啉类化合物将在肿瘤生物成像中作为造影剂，以及在溶胶-凝胶结合光学传感器和/或双光电/电化学金属离子传感器等应用中非常有用。学生和博士后同事将不仅在这些化合物的合成和物理表征方面获得基本和多样化的技能，而且还将探索所得产物在催化，生物成像和传感器方面的潜在应用。

The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the work of Dr. Brian Hoffman (as the PI) of the Department of Chemistry at Northwestern University, and Anthony Barrett (as co-PI) of Imperial College, London UK, for their collaborative work on star porphyrazines (pzs). Specifically, they will (i) investigate multi-metallic pzs and pz multimers that will exhibit macrocycle-mediated spin coupling among the localized moments in the metal ions; (ii) examine porphyrazine assemblies and metal-linked pz ribbons that incorporate redox-switchable conduction and/or spin coupling; (iii) explore metal-porphyrazine systems as contrast agents in optical tumor imaging; (iv) examine charged pzs containing an active central metal ion (e.g. Fe or Mn) as possible catalysts for peroxynitrite decomposition; and (v) explore the usefulness of porphyrazines with peripheral substituents designed to bind redox-active metals in applications as sol-gel incorporated optical sensors and/or as dual opto/electrochemical metal-ion sensors.The work supported by this award will have significant impact on a variety of scientific and technological applications. The class of compounds known as star porphyrazines will be highly useful as contrast agents in bio-imaging of tumors, and in such applications as sol-gel incorporated optical sensors and/or as dual opto/electrochemical metal-ion sensors. Students and post-doctoral associates will gain fundamental and diverse skills not only in syntheses and physical characterization of these compounds, but also in exploring the potential application of the resulting products in catalysis, bio-imaging, and sensors.