Postdoctoral Research Fellowship in Microbial Biology for FY2001

这一行动为2001财年NSF微生物生物学博士后奖学金提供了资金。该奖学金支持关于原生动物、微藻、真菌、古生物、细菌和病毒物种的基本生物学的培训和研究，这些物种通常不被认为是模式生物。此外，它还为最近的博士获得者提供了获得微生物生物学方面的额外培训的机会，在知名科学家的赞助下获得研究经验，并在本科生和研究生培训期间拓宽其科学视野，超越研究经验。这些奖学金还旨在帮助新科学家引导他们的研究工作跨越传统的学科界限，并利用独特的研究资源、地点和设施，包括外国地点。这项研究和培训计划的标题是“利用生化和遗传方法剖析蓝藻如何感知和响应不断变化的光照条件。”试验菌为双虹吸Fremyella。目前正在对RcaE进行详细的生化分析，RcaE是一种可能的光敏色素样光感受器，控制着互补染色适应(CCA)的过程。具体地说，实验针对的是磷继电器模型，该模型认为RcaE是光感受器，在不同的光质中差异地控制反应调节器RcaF的磷酸化状态，而RcaF反过来调节RcaC的磷酸化水平。

This action funds an NSF Postdoctoral Fellowship in Microbial Biology for FY2001. The fellowship supports training and research on the basic biology of protozoan, microalgal, fungal, archaeal, bacterial and viral species that are not generally considered to be model organisms. Further, it provides opportunities for a recent doctoral recipients to obtain additional training in microbial biology, to gain research experience under the sponsorship of established scientists, and to broaden his/her scientific horizons beyond the research experiences during the undergraduate and graduate training. These fellowships are further designed to assist new scientists to direct their research efforts across traditional disciplinary lines and to avail themselves of unique research resources, sites, and facilities, including foreign locations. The research and training plan is entitled "Utilizing biochemical and genetic methods to dissect how a cyanobacterium senses and responds to changing light conditions." The test organism is Fremyella diplosiphon. A detailed biochemical analysis is being made of RcaE, a putative phytochrome-like photoreceptor that controls the process of complementary chromatic adaptation (CCA). Specifically, the experiments address the phosphorelay model which holds that RcaE is the photoreceptor that differentially controls the phosphorylation state of the response regulator RcaF in different light qualities, which in turn regulates the phosphorylation levels of RcaC.