Acquisition of a Transmission Electron Microscope to Support UCR's Accelerated Growth in the Cell/Molecular/Development Biology Program

詹姆斯·G博士获得了一笔赠款。鲍德温在加州大学滨江（UCR）的一个新的透射电子显微镜（TEM）。这个不断增长的校园和现有显微镜的调度问题的研究和教学需求将通过增加这个新的TEM得到满足。 新的显微镜与现有的TEM高度互补，这两种仪器将被安置在自然和农业科学学院（CNAGS）管理的高级显微镜和微量分析中心（CFAMM）中。 该仪器提供了专家所需的功能，但学生和经验不足的显微镜工作者欣赏的简单性。 新的显微镜将被安排用于利用其易用性的项目，用于许多生物学研究人员和学生所做的各种TEM工作，这些工作不需要高加速电压也不需要分析能力。 灵活性和调度冲突将进一步解决配备电子控制旋转阶段的显微镜（许多细胞、分子和发育生物学[CMDB]）研究者，例如那些使用立体对的研究者所需要的）和数字图像捕获，这些是大多数CMDB科学家所需要的，并且对于成本有效的打印、存储、3D重建、并且与相邻的视觉计算中心（CVC）的接口很容易，它将通过现有的光纤系统与CVC连接。 一个新的真空蒸发器也被授予，是至关重要的样品制备的电子显微镜。UCR是发展最快的UC校园，少数民族学生在UC系统中的代表性最高，在全国范围内也是最高的。 新的教师招聘和新的实验室建设正在进行中，以适应到2010年100%的增长，特别是生命科学的增长。 新的TEM对于研究和教学计划至关重要，以跟上CMDB迅速扩大的跨部门计划的步伐，并解决校园内唯一现有的现代TEM上日益恶化的调度危机，并由生命和材料科学家共享。 对于联邦资助的UCR生命科学研究人员的重要群体来说，TEM是一种不可或缺的工具，与一系列用于在细胞和亚细胞水平上获取结构信息的其他技术相辅相成。 这些包括与基础科学以及农业，生物医学，发病机制，抗生素的作用模式以及探索进化中的特征变化相关的细胞生物学中的特殊应用。 UCR现有的CFAMM与CVC接口，为新的TEM提供了一个独特的环境，专门用于生命科学/CMDB研究和培训。 新的TEM将成为现有七门课程的主要研究生和本科生TEM教学工具，本提案的PI将合作开发一门新的培训课程，专门针对CFAMM新仪器周围的TEM技术。

A grant has been awarded to Dr. James G. Baldwin at The University of California, Riverside (UCR) for a new transmission electron microscope (TEM). The research and teaching needs of this growing campus and scheduling problems on the existing microscope will be met by adding this new TEM. The new microscope is highly complementary with the existing TEM and both instruments will be housed and administered together in the campuswide Central Facility for Advanced Microscopy and Microanalysis (CFAMM) administered within the College of Natural and Agricultural Sciences (CNAGS). This instrument provides functionality needed by experts, yet simplicity appreciated by students and less experienced microscopists. The new microscope will be scheduled for projects that leverage its ease-of-use for diverse TEM work done by many biology researchers and students that do not require high accelerating voltage nor analytical capabilities. Flexibility and scheduling conflicts will be further addressed by equipping the microscope with an electronically controlled rotating stage (required by many Cell, Molecular and Developmental Biology [CMDB]) investigators, e.g. those using stereo pairs) and digital image capture required for most CMDB scientists and crucial for cost effective printing, storage, 3D reconstruction, and easy interfacing with the adjacent Center for Visual Computing (CVC) with which it will be linked by an existing fiber optics system. A new vacuum evaporator is also awarded and is vital for sample preparation for the electron microscope. UCR is the most rapidly growing UC campus, with the highest representation of minority students in the UC system and among the highest nationally. New faculty hires and new laboratory construction are underway to accommodate a 100% increase by 2010, with particular growth in life sciences. The new TEM is essential for research and teaching programs to keep pace with the rapidly expanding interdepartmental program in CMDB and to address a worsening scheduling crisis on the only existing modern TEM on campus and shared by both life and materials scientists. For a significant group of Federally-funded UCR researchers in the life sciences, TEM is an indispensable tool, complementary to a range of additional techniques for acquiring structural information at the cellular and sub-cellular level. These include special applications in cell biology that are relevant to basic science as well as agriculture, biomedicine, pathogenesis, mode of action of antibiotics, and exploring character changes in evolution. UCR's existing CFAMM, interfaced with the CVC, provides a unique context for the new TEM dedicated for life science/CMDB research and training. The new TEM will be the primary graduate and undergraduate TEM teaching tool for seven existing courses, and the PIs of this proposal will collaborate to develop a new training course specific to TEM techniques centered around the new instrument at the CFAMM.