The Kinetic Resolution of Chiral alpha-Olefins with Optically Active Ansa-Zirconocene Polymerization Catalysts

这项研究的目的是由教授约翰E。Bercaw在加州理工学院，这是由无机，生物无机和有机化合物化学计划的支持，是开发新的，高反应性的对映体纯预催化剂，显示出改善的选择性和底物的一般性手性α-烯烃。 由于它们在聚合α-烯烃中的极端活性，光学活性柄型-二茂锆聚合催化剂是实现动力学拆分、优先聚合手性烯烃的一种对映异构体并留下反应性较低的对映异构体的极好前景。 这不仅可以拆分两种对映体，还可以得到一类新的光学活性聚合物。将开发新的催化剂来拆分左右手分子，这对于合成药物等手性分子至关重要。 通过使用聚合催化剂，一种类型的“手”分子被引入到一种新型的“手”聚合物中。

The objective of this research by Professor John E. Bercaw at the California Institute of Technology, which is supported by the Inorganic, Bioinorganic and Oganometallic Chemistry Program, is to develop new, highly reactive enantiopure precatalysts that show improved selectivity and substrate generality for chiral alpha-olefins. Due to their extreme activities in polymerizing alpha-olefins, optically active ansa-zirconocene polymerization catalysts are excellent prospects for effecting kinetic resolutions, preferentially polymerizing one enantiomer of a chiral olefin and leaving behind the less reactive enantiomer. This not only resolves the two enantiomers, but also leads to a new class of optically active polymers.New catalysts will be developed to resolve right- and left handed molecules, which is essential for synthesizing chiral molecules such as pharmaceuticals. By using a polymerization catalyst, one type of "handed" molecule is incorporated into a new type of "handed" polymer.