SBIR Phase I: Fast Response Sensor for Airborne Biological Particles

这个小型企业创新研究（SBIR）第一阶段项目提出开发一种新型的光电传感器，能够捕获单个空气颗粒并在几分钟的时间尺度上分析其成分。传感器的概念是基于以前开发的单粒子电动捕获和拉曼光谱创新技术。电动捕集器能够捕获和悬浮尺寸为1至100 μ m的单个气载颗粒。通过拉曼光谱分析捕获的粒子提供了粒子的化学成分的振动结构的指纹，类似于通过红外吸收光谱获得的指纹，但是具有单粒子灵敏度。这又导致将颗粒鉴定为细菌或其他，以及细菌物种的初步鉴定。在第一期项目中，将设计一种紧凑的传感器，该传感器可以在几分钟的时间尺度上连续筛选周围栖息地的空气并分析每个捕获的颗粒。该项目的商业应用是在国防和健康相关行业。

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel, electro-optical sensor capable of capturing single airborne particles and analyzing their compositions on a time scale of a few minutes. The sensor concept is based on a previously developed innovative technology for single-particle electrodynamic capture and Raman spectroscopy. The electrodynamic trap is capable of capturing and suspending single airborne particles of sizes 1 to 100 m. Analysis of the trapped particle by Raman spectroscopy provides a fingerprint of the vibrational structures of the particle's chemical components, analogous to that obtained by infrared absorption spectroscopy, but with single-particle sensitivity. This in turn leads to identification of the particle as bacterial or otherwise, as well as to preliminary identification of the bacterial species. In this Phase I project, a compact sensor that can continually screen ambient habitat air and analyze each trapped particle on a time scale of minutes will be devised.The commercial application of this project is in defense and health-related industries.