Postdoctoral Research Fellowship in Interdisciplinary Informatics for FY 2003

跨学科信息学博士后研究奖学金由数学和物理科学（MPS）和生物科学（BIO）理事会联合赞助，以鼓励跨越它们之间传统学科界限的研究和培训。这些奖学金为生物学和信息学的跨学科研究和教育活动提供了机会，以广泛的近期博士获得者（生物学家，化学家，物理学家，数学家，统计学家，计算机科学家等）。预期通过这些研究金培训的研究员将在培训未来劳动力方面发挥重要作用。信息学方面的博士后研究和培训将允许生物学、数学、化学和物理科学方面的初级科学家在开发新的定量工具和方法方面发挥关键作用，这些工具和方法将推动生物学和其他领域的信息学。研究和培训计划的题目是“电压激活的机电模型”。电压门控离子通道对于触发神经分泌和肌肉收缩的动作电位的产生至关重要。膜去极化引起传导所需的电压感应畴的重排。本项目将利用静电计算构建分子模型，以了解钾离子通道中的这些运动。

Postdoctoral Research Fellowships in Interdisciplinary Informatics are sponsored jointly by the Directorates for Mathematical and Physical Sciences (MPS) and Biological Sciences (BIO) to encourage research and training that cross the traditional disciplinary boundaries between them. These fellowships provide opportunities for interdisciplinary research and educational activities in biology and informatics to a wide range of recent doctoral recipients (biologists, chemists, physicists, mathematicians, statisticians, computer scientists, and others). It is expected that the Fellows trained through these fellowships will play an important role in training the future workforce. Postdoctoral research and training in informatics will permit junior scientists trained in biology, mathematical, chemical, and physical sciences to play key roles in developing new quantitative tools and methods that will advance informatics in biology and other fields.The research and training plan is entitled "Electromechanical models of voltage-activation." Voltage-gated ion channels are essential for the generation of action potentials that trigger neurosecretion and muscle contraction. Membrane depolarization causes rearrangements of a voltage-sensing domain required for conduction. This project will construct molecular models using electrostatic calculations in order to understand these motions in potassium channels.