PostDoctoral Research Fellowship

这项NSF少数民族博士后研究奖学金将支持研究和培训少数民族学者从事分子人类学工作，特别是对秘鲁土著人口遗传多样性的基于Y染色体的研究。该项目将为研究人员提供分子人类学方法和理论方面的广泛培训经验，这种培训将补充和补充她之前在密歇根大学的博士学位工作。这个为期两年的项目将主要在新墨西哥大学的Anne C. Stone博士的实验室进行，偶尔会与b博士进行合作培训和技术工作。圣马科斯国立大学校长Lizarraga和秘鲁利马里卡多帕尔马大学校长V.Rubin。拟议的项目是对秘鲁土著Y染色体遗传多样性的深入研究。具体而言，该项目的目的是：(1)通过密集的人口抽样确定秘鲁土著群体的Y染色体遗传多样性特征；(2)一方面测试遗传多样性措施与可能形成这些土著群体遗传结构的变量（包括过去的人口统计事件）之间的重要相关性；(3)在区域（秘鲁/安第斯）和大陆（南美洲）范围内进行这些测试。研究的重点是染色体的非重组成分（NRY），以解决秘鲁土著群体的群体遗传结构。群体亲和性、遗传多样性水平和基因流动将使用群体遗传分析进行检验。Y染色体单倍型将构成这些比较的基础，这些比较将使用相对缓慢突变的单核苷酸多态性（SNPs）和更快突变的短串联重复序列（STRs）的组合来构建。到目前为止，Lizarraga博士和V. Rubin博士为了这个项目的目的，已经从不同地理区域和语言家庭的6个人群中抽样了100多人。

This NSF Minority Post Doctoral Research Fellowship will support research and training for a minority scholar to work in molecular anthropology, specifically for a Y chromosome-based study on the genetic diversity of Native Peruvian populations. The project will provide the researcher extensive training experience in method and theory of molecular anthropology, and this training will both complement and supplement her previous Ph.D. work at the University of Michigan. This two-year project will be carried out primarily in the laboratory of Dr. Anne C. Stone of the University of New Mexico, supplemented with occasional collaborative training and technical work with Dr.B.Lizarraga, Universidad Nacional Mayor de San Marcos, and V.Rubin, Universidad Ricardo Palma, Lima, Peru. The proposed project is in depth study of Native Peruvian Y chromosome genetic diversity. Specifically, the project aims to: (1) characterize Y chromosomal genetic diversity in Native Peruvian groups via intensive population sampling, (2) test for significant correlations between genetic diversity measures, on the one hand, and variables that may have shaped genetic structure of these native populations, including past demographic events, on the other, and (3) conduct these tests on both a regional (Peruvian / Andean) and continental (SouthAmerican) scale. The study focuses on the non-recombining component (NRY) of the chromosome to resolve the population genetic structure of Native Peruvian populations. Population affinity, level of genetic diversity and gene flow will be examined using population genetic analyses. Y chromosomal haplotypes will form the basis of these comparisons, and these will be constructed using combinations of relatively slow mutating Single Nucleotide Polymorphisms (SNPs) and faster mutating Short Tandem Repeats (STRs). Thus far, Dr. Lizarraga and V. Rubin have sampled over 100 individuals from 6 populations throughout diverse geographic areas and linguistic families for the purposes of this project.