Structure, Reorganization Dynamics and Reactivity of Self Assembled Carbanionic Species

在化学系有机动力学项目的支持下，俄亥俄州立大学的吉迪恩·弗拉恩克尔教授建议将重点放在由选定类别的有机锂化合物的结构和行为揭示的碳离子物质上。其目的是将结构与其快速平衡重组的动力学和机制以及它们的化学行为联系起来。结构将通过X射线结晶学和新的核磁共振实验进行研究，而动态信息将通过质子、13C、6Li、7Li和15N核磁共振线形分析获得。DFT计算将被用于分析结果，并帮助预测未来可能进行的研究的新的有趣的系统。化学系的有机和高分子化学项目支持俄亥俄州立大学的吉迪恩·弗拉恩克尔教授，他将利用包括有机和有机金属合成、动态核磁共振、密度泛函计算和X射线结晶学在内的许多化学领域来研究关键问题。Fraenkel教授的研究为参与这项研究的女性和其他无代表群体的成员提供了更多的就业市场机会。以前的学生既进入了传统领域，也进入了非传统领域。弗雷恩克尔博士在1997-2000年间是REU网站的PI，他管理该系的本科生研究项目长达六年之久。REU项目在从传统的黑人大学招收有才华的学生方面尤其成功。弗拉恩克尔教授的研究使人们对有机锂化合物及其在反应中的用途有了基本的了解。来自全国各地的许多团体已经就涉及有机锂化合物的合成问题向该团体进行了咨询。例如，研究成果和咨询使固特异轮胎橡胶公司、康奈尔大学的研究人员和默克公司等机构受益。

With the support of the Organic Dynamics Program in the Chemistry Division, Professors Gideon Fraenkel at Ohio State University proposes to focus on carbanionic substances as revealed by the structure and behavior of selected categories of organolithium compounds. The objective is to correlate structures with the dynamics and mechanisms of their fast equilibrium reorganizations and their chemical behaviors. Structure will be investigated with X-ray crystallography and new NMR experiments while dynamic information will be obtained using proton, 13C, 6Li, 7Li and 15N NMR line shape analyses. DFT calculations will be used to analyze the results and help predict new interesting systems for possible future study. Model compounds have been designed to reveal specific aspects of structure and dynamics.The Organic and Macromolecular Chemistry Program in the Chemistry Division supports Professor Gideon Fraenkel at Ohio State University who will utilize many areas of chemistry including organic and organometallic synthesis, dynamic NMR, DFT calculations and X-ray crystallography to examine critical problems. Professor Fraenkel's have provided enhanced opportunities in the job market for women and members of other unrepresented groups who have participated in the research. Former students have entered both traditional and non-traditional fields. Dr. Fraenkel was PI of the REU site here 1997-2000 and he administered the department's undergraduate research program for six years. The REU program was particularly successful in recruiting talented students from traditionally black colleges. Professor Fraenkel's research is leading to a fundamental understanding of organolithium compounds and their use in reactions. Many groups from all over the country have consulted with the group on their synthetic problems involving organolithium compounds. For example, research results and consultations have benefited institutions such as Goodyear Tire and Rubber Co, researchers at Cornell University, and Merck Co.