Acquisition of a Hybrid Small/Macromolecule X-Ray Diffractometer System

在主要研究仪器（MRI）项目的支持下，肯塔基大学的Sean Parkin和他的同事将购买一个带有SMART CCD探测器的小/大分子混合x射线衍射仪系统。该仪器将包括旋转阳极双源x射线发生器、k轴测角仪、聚焦光学和低温装置。pi将研究多态性、超结构、绝对立体化学、高活性/不稳定化合物、电荷密度分析和蛋白质结构。该地区许多小型机构的教师也可以免费使用。x射线衍射仪可以精确测量分子的完整三维结构，包括键的距离和角度，并提供分子相对于邻近分子的空间排列的准确信息。这些研究将对包括聚合物科学和生物化学在内的许多领域产生影响。

With support from the Major Research Instrumentation (MRI) Program, Sean Parkin and colleagues at the University of Kentucky will purchase a hybrid small/macromolecule X-ray diffractometer system with a SMART CCD detector. The instrumentation will include a rotating anode dual source X-ray generator, k-axis goniometer, focusing optics and low-temperature apparatus. The PIs will investigate polymorphism, superstructures, absolute stereochemistry, highly reactive/unstable compounds, charge density analysis and protein structure. Faculty at numerous small institutions in the area will also have access at no charge. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, including polymer sciences and biochemistry.