SBIR Phase I: Recombinant Infectious Hematopoietic Necrosis (IHN ) Virus G Protein Vaccine

这个小企业创新研究第一阶段项目是开发一种疫苗，用于控制鲑鱼和鳟鱼的传染性造血坏死（IHN）病。一种有效、安全且价格合理的IHN病毒疫苗将提高太平洋西北地区鳍鱼养殖业的生产力，确保商业和休闲渔业的生产力，并减少与野生和养殖鱼类之间IHN病毒传播有关的环境问题。水产养殖业在北美偏远和农村地区创造了就业机会。这些工作受到流感反复爆发的威胁。此外，本项目将研究IHN病毒的糖蛋白如何在鳟鱼和鲑鱼中引发非特异性的交叉保护免疫反应。这些信息将有助于开发新的病毒疫苗和佐剂。该项目的商业应用是在水产养殖领域。IHN病毒疫苗将为北美水产养殖业带来重大利益。该产品将销售给加拿大西部和美国的非商业和商业鲑鱼和鳟鱼养殖企业。

This Small Business Innovation Research Phase I project is to develop a vaccine for the control of infectious hematopoietic necrosis (IHN) disease of salmon and trout. An efficacious, safe and reasonably priced IHN virus vaccine would improve the productivity of the finfish aquaculture industry in the Pacific Northwest, ensure the productivity of commercial and recreational fisheries, and reduce environmental concerns related to IHN virus transmission between wild and farmed fish. The aquaculture industry has created jobs in remote and rural areas of North America. These jobs are threatened by recurrent IHN outbreaks. Additionally, this project will investigate how the glycoprotein of IHN virus elicits a non-specific, cross-protective immune response in trout and salmon. Such information will be helpful in developing new viral vaccines and adjuvants. The commercial application of this project is in the area of aquaculture. The IHN virus vaccine will provide a significant benefit to the North American aquaculture industry. The product will be marketed to non-commercial and commercial salmon and trout farming enterprises in western Canada and the United States.