Workshop on Signaling, Gene Expression and Cell Fate; Fall 2003; Aspen, Colorado

细胞生物学最有趣的方面之一--也是本提案中讨论的研讨会的主要主题之一--是研究外部或内部信号如何改变基因表达并影响对不同细胞命运的承诺。生物学实验方法的最新进展，结合物理/数学科学家开发的计算工具，为分析潜在的复杂信号和遗传网络提供了一种新的途径。研讨会将于2003年8月18日至9月7日在科罗拉多州阿斯彭的阿斯彭物理中心举行，主要目的有两个：(A)将已经从事生物激励研究的物理学家与主要生物学家聚集在一起，以加强现有的合作并促进新的合作；以及(B)向感兴趣的物理学家介绍生物研究的前沿问题。阿斯彭物理中心为这种互动提供了一个非正式和激动人心的理想环境。此外，该中心在促进跨学科生物学研究方面发挥了主导作用，目前正计划每年冬天用一周时间，夏天用三到六周时间来参加以生物为动力的会议和项目。

0326520OlintoOne of the most interesting aspects of cell biology -- and the main subject of the Workshop discussed in this proposal -- is the study of how external or internal signals modify gene expression and affect the commitment to different cellular fates. Recent progress in experimental methods in biology, combined with computational tools developed by physical/mathematical scientists, provides a new way of analyzing the underlying complex signaling and genetic networks.The workshop will take place during the period August 18 - September 7, 2003, at the Aspen Center for Physics in Aspen, Colorado, and has two principal aims: (a) to bring together physicists already working on biology-motivated research with key biologists in order to strengthen existing collaborations and foster new ones; and (b) to introduce interested physicists to problems at the forefront of biological research. The Aspen Center for Physics provides an informal and stimulating environment ideal for such interactions. Moreover, the Center has played a leading role in promoting interdisciplinary Biology research and is currently planning to dedicate one week each winter and three-to-six weeks each summer to biology-motivated conferences and programs.