SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease

在生理稳定状态和疾病状态下，免疫细胞的运输是免疫监测的关键前提。适当的免疫监测对哺乳动物的动态平衡至关重要，因为它确保了对病原体入侵者的防御，也因为它通过不断清除死亡细胞来保证组织的完整性。为了既有功能又有效率，免疫细胞的迁移和运输行为必须根据需求进行精确控制和微调。由于免疫细胞的贩运不遵循统一的过程，这项关键任务变得复杂起来。事实上，不同类型的免疫细胞被赋予了独特的机制，允许它们追逐特定于亚群的运输路线，以便在各自的目标组织内完成各自的任务。到目前为止，控制和组织这一复杂的哺乳动物免疫细胞运输过程的分子和细胞特征仍然不完全清楚。因此，CRC914的任务是剖析在炎症、发育和疾病状态下调节不同白细胞亚群迁移反应的信号和机制。一个题为“贩运白细胞”的综合研究培训小组是我们科学工作的侧翼。从长远来看，CRC914旨在通过专门和选择性地针对不同白细胞亚群的已确定的迁移模式，为急慢性感染性和非感染性炎症性疾病期间治疗干预措施的创新概念的发展做出贡献。

Trafficking of immune cells is a key prerequisite for immune surveillance under physiological steady state conditions and during disease states. Proper immune surveillance is of utmost importance in mammalian homeostasis as it ensures defense against pathogen intruders, but also because it guarantees tissue integrity through the continuous removal of dying cells. In order to be both functional and efficient, the migration and trafficking behavior of immune cells has to be precisely controlled and fine-tuned on demand. This critical task is complicated by the fact that trafficking of immune cells does not follow a uniform process. Indeed, different types of immune cells are rather endowed with unique machinery allowing them to chase subset-specific trafficking routes in order to fulfill their individual tasks within their individual target tissues. To date, the molecular and cellular signatures that control and organize this complex process of mammalian immune cell trafficking are still incompletely understood. It is therefore the mission of CRC 914 to dissect the signals and mechanisms that regulate the migratory responses of distinct leukocyte subsets during inflammation, development and in disease states. An Integrated Research Training Group entitled “Leukocyte Trafficking” flanks our scientific efforts. As a long-term perspective, CRC 914 aims to contribute to the development of innovative concepts for therapeutic interventions during acute and chronic infectious and non-infectious inflammatory diseases by specifically and selectively targeting the identified migratory patterns of distinct leukocyte subsets.