Physical Chemistry of Virus-like Particles

在这个奖项中，由化学部的实验物理化学和理论与计算化学计划以及分子和细胞生物科学部的分子生物物理计划支持，教授。Charles M.作者声明：William M.加州大学洛杉矶分校的Gelbart将对带电聚合物在病毒样衣壳容器中的封装物理进行合作实验和理论研究。 将使用各种实验技术，包括传统的生物化学方法，以及原子力显微镜和光散射研究。 这项工作的理论方面将涉及把各种传统的理论工具结合起来，以解决这一难题。Knobler和Gelbart应该有助于提供理解病毒RNA的折叠机制所必需的基本信息。 此外，从这项研究中获得的信息类型也应该有助于理解各种其他生物物理过程，如染色体的形成，该研究应该有助于指导药物递送载体的仿生设计。 与教授一起工作的学生和博士后研究员。Knobler和Gelbart应该从参与独特的跨学科努力中受益。

In this award, supported by the Experimental Physical Chemistry and Theoretical and Computational Chemistry Programs of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, Profs. Charles M. Knobler and William M. Gelbart of University of California, Los Angeles will conduct collaborative experimental and theoretical research on the physics of encapsulation of charged polymers in virus-like capsid containers . A variety of experimental techniques will be used, including traditional biochemical methods, as well as atomic force microscopy and light-scattering studies. The theoretical aspect of the work will involve bringing together a variety of traditional theoretical tools to bear on this difficult problem.The studies by Profs. Knobler and Gelbart should help to provide the kind of basic information necessary to understand the mechanics of encapsidation of viral RNA. In addition, the types of information obtained from this study should also be useful in understanding a variety of other biophysical processes, such as the formation of chromosomes, and the research should help to guide biomimetic design of drug-delivery vehicles. The students and postdoctoral fellows working with Profs. Knobler and Gelbart should benefit from participating in a unique, interdisciplinary effort.