NIRT: Nanohybrids and Nanobiohybrids, Bottom-Up Approach to Nanopatterned Surface Arrays and Application

这个纳米级跨学科研究小组(NIRT)由材料研究部、化学和运输系统部以及工程教育和中心部共同资助，将开发一种基于嵌段共聚物在硅上组装二氧化硅纳米结构并随后进行激光诱导熔化的“自下而上”方法，以生成间隔至分子水平(~10 nm)的硅表面阵列。其目的是了解支配这些结构创造的动力，以及发明能够在不使用传统光刻的情况下以低成本制造大面积此类纳米结构的使能技术。在第一个应用中，我们将设计表面以整合生物分子，即匹配抗体的自然间距。该团队由B.Baird、D.Muller、S.Gruner、C.Ober(合作者)、M.Thompson和U.Wiesner组成。这项工作属于美国国家科学基金会的研究和教育主题“纳米级结构、新现象和量子控制”和(在较小程度上)“纳米级设备和系统架构”。理解纳米结构薄膜的形成和纳米阵列的形成，包括表面润湿和小尺寸晶体生长的影响，将对纳米技术的许多领域产生影响。如果成功，我们将能够以低廉的成本制造大面积的这种纳米结构，而不需要使用传统的光刻技术。这将向许多目前无法使用如此昂贵的设施的人开放这一领域。此外，将合成材料的表面结构设计成生物分子的分子结构，构成了纳米生物技术的一个强大范例，并可能导致完全新颖的组织方式，例如，在用于分析和检测的固体基质上组织蛋白质。康奈尔大学在这一领域具有得天独厚的优势，该计划将有效利用康奈尔大学的设施，如康奈尔高能同步加速器源(CHESS)以及康奈尔材料研究中心(CCMR)和纳米生物技术中心(NBTC)的设施。拟议活动产生的广泛影响通过从有机合成到材料表征到生物等活动的协作环境，我们将促进一种教学、培训和学习的方式，从而为不经常获得的博士后研究人员、研究生和本科生提供独特的教育体验。我们还将涉及人力资源培训和开发的其他组成部分，包括代表人数不足的群体的参与、加强研究和教育基础设施的努力以及工业外展。为此，我们打算与美国国家科学基金会资助的康奈尔材料研究中心(CCMR)和纳米生物技术中心(NBTC)提供的优秀和成熟的平台合作。特别是，由于巨大的乘法效应，我们将发展教师教学教师(T3)研讨会，提供可以带回教室的动手课程，我们将在与西蒙斯学院(一所主要的女子学院)成功合作的基础上，向学生介绍纳米科学和工程的概念。

This Nanoscale Interdisciplinary Research Team (NIRT), cofunded by the Division of Materials Research, the Division of Chemical and Transport Systems, and the Division of Engineering Education and Centers, will develop a "bottom-up" approach based on block copolymer directed thin film assembly of silica nanostructures on silicon and subsequent laser induced melting to generate silicon surface arrays with spacings down to the molecular level (~10 nm). The aim is to understand the dynamics governing creation of these structures, as well as to invent enabling technologies that will allow inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. In a first application we will engineer the surfaces towards integration of biomolecules, i.e., to match the natural spacing of an antibody. The team consists of B. Baird, D. Muller, S. Gruner, C. Ober (collaborator), M. Thompson, and U. Wiesner. This work falls into the NSF research and education themes "Nanoscale Structures, Novel Phenomena, and Quantum Control" and (to a lesser extend) "Nanoscale Devices and System Architecture". Intellectual merit of the proposed activityUnderstanding nanostructured thin film formation and nanopillar array formation including the effects of surface wetting and crystal growth in small dimensions will have impact on many areas of nanotechnology. If successful we will enable technologies for the inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. This will open up the field to many which currently don't have access to such expensive facilities. Furthermore, engineering the surface structure of a synthetic material towards the molecular architecture of a biomolecule constitutes a powerful paradigm for nanobiotechnology and may lead to completely novel ways of organizing, e.g., proteins on solid substrates for analysis and detection. Cornell is uniquely positioned to make advances in this field and the program will make effective use of Cornell facilities such as the Cornell High Energy Synchrotron Source (CHESS) as well as facilities of the Cornell Center for Materials Research (CCMR) and the Nanobiotechnology Center (NBTC).Broader impacts resulting from the proposed activity Through the collaborative environment with activities ranging from organic synthesis to materials characterization to biology we will promote a way of teaching, training, and learning and thus a unique educational experience for postdoctoral researchers, graduate and undergraduate students not frequently obtained. We will also involve other components of training and development of human resources including the participation of underrepresented groups, efforts to enhance the infrastructure for research and education, and industrial outreach. To this end we intend to work with the excellent and proven platforms provided by the NSF funded Cornell Center for Materials Research (CCMR) and Nanobiotechnology Center (NBTC). In particular, because of the large multiplication effect we will develop Teacher Teaching Teacher (T3) workshops with hands-on lessons that can be brought back into the classrooms, and we will build on a successful collaboration with Simmons College, a primary female college, to introduce students to concepts of nanoscale science and engineering.