Non-cellautonomous role of the endoribonuclease ENDU-2/ENDOU/PP11 in tumorigenesis and invasion (A06)

我们在秀丽隐杆线虫中建立了微环境因素对干细胞重编程和过度增殖的影响模型，该模型还允许研究肿瘤细胞从其生态位迁移和侵袭。enu -2核糖核酸内切酶足以诱导种系肿瘤发生，将在秀丽隐杆线虫和人类细胞培养中通过生化和遗传实验相结合进行研究。

A model for stem cell reprogramming and hyperproliferation by microenvironmental factors was established in C. elegans that additionally allows for studies of migration and invasion of tumor cells from their niche. The endoribonuclease ENDU-2 is sufficient for the induction of germline tumorigenesis and will be studied by a combination of biochemical and genetic experiments in C. elegans and human cell culture.