Acquisition of High Throughput DNA Sequencing and Genotyping Instrumentation for Research and Training

在Luis Actis博士的指导下，向俄亥俄州牛津的迈阿密大学提供了一笔赠款，用于购置使用现代分子技术进行高通量DNA研究的仪器，例如自动DNA核苷酸测序和片段分析以及各种生物体和微生物的基因表达。该仪器还包括使用自动化和手动生物信息学工具收集、存储和分析核苷酸序列和DNA片段数据的硬件和软件。这些研究的最终和共同目标是了解原核和真核基因组的结构和进化及其在不同环境条件下的表达。获得本项目中描述的最先进的仪器，可以同时处理和分析大量样品，将有助于实现这些项目的研究，教学和培训目标。该奖项将支持广泛科学领域的研究和培训活动，包括细菌和病毒基因组学，微生物多样性，环境基因组学，进化生物学，功能基因组学和蛋白质生物化学。这些活动由在植物学、化学/生物化学、地质学、微生物学和动物学部门工作的积极研究人员进行。此外，作为该奖项的直接结果，与计算机科学系对生物信息学和计算生物学感兴趣的教师的互动将得到加强。这些学术活动的目标之一是将现代多学科研究方法引入遗传水平上研究复杂的生物学问题，同时指导和培训迈阿密大学的教师，员工和学生在生物信息学，基因组学，获得仪器的更广泛意义在于，它将使迈阿密大学继续致力于不断增强学术课程，这将提供上级教学和研究经验，为本科生和研究生在当前和新兴的科学领域。除了将获得更好的教育体验的学生数量外，这些学生的质量和多样性也将受到这种仪器和技术的影响。迈阿密大学致力于吸引学生以及教师属于少数民族和代表性不足的群体寻找科学高等教育。该仪器还将促进新的研究计划以及具有共同研究兴趣的科学家之间的合作。最终，所有这些活动都应服务于社区，向新一代提供现代技术方面的指导和培训，以研究复杂和重要的生物问题和过程。

A grant has been awarded to Miami University at Oxford, Ohio, under the direction of Dr. Luis Actis for the acquisition of instrumentation for high-throughput DNA studies using modern molecular techniques, such as automated DNA nucleotide sequencing and fragment analysis as well as gene expression in a wide range of organisms and microorganisms. This instrumentation also includes hardware and software to collect, store, and analyze nucleotide sequences and DNA fragment data using automated and manual Bioinformatics tools. The ultimate and common goals of these studies are the understanding of the structure and evolution of prokaryotic and eukaryotic genomes and their expression under different environmental conditions. The acquisition of the state-of-the-art instrumentation described in this project, which allows the simultaneous processing and analysis of large number of samples, will facilitate the achievement of the research, teaching and training goals of these projects.This award will support research and training activities in a broad array of scientific fields including Bacterial and Viral Genomics, Microbial Diversity, Environmental Genomics, Evolutionary Biology, Functional Genomics, and Protein Biochemistry. These activities are conducted by active investigators working in the departments of Botany, Chemistry/Biochemistry, Geology, Microbiology, and Zoology. In addition, interactions with faculty in the Computer Science department interested in Bioinformatics andComputational Biology will be enhanced as a direct consequence of this award. One of goals of these academic activities is to bring modern multidisciplinary research approaches to study complex biological problems at the genetic level while instructing and training faculty, staff, and students at Miami University in the emerging fields of Bioinformatics, Genomics, and Computational Biology.The broader significance of the acquired instrumentation is that it will allow Miami University to continue with its commitment to the constant enhancement of the academic programs, which will provide superior instructional and research experiences for undergraduate and graduate students in current and emerging scientific fields. In addition to the number of students who would receive an improved educational experience, the quality and diversity of these students will be impacted by this instrumentation and technology. Miami University is committed to attract students as well as faculty members belonging to minority and underrepresented groups looking for higher education in science. This instrumentation will also foster new research programs as well as collaborations among scientist with common research interests. Ultimately, all these activities should serve the community by instructing and training new generations in modern technology used to study complex and significant biological problems and processes.